Why Choose a Removable Over-The-Scope Clip for the Treatment of Gastrointestinal Bleeding, Perforation, and Defects?

Gastrointestinal bleeding, perforation, and fistulas are common conditions in gastroenterology. Endoscopic hemostasis and defect closure have become the preferred minimally invasive clinical approaches. Conventional endoscopic clips are well-established and effective for acute-phase hemostasis and tissue closure. However, once deployed, they cannot be actively removed. Long-term retention of these clips carries the potential risk of local foreign-body reactions and granulation tissue hyperplasia, and may also interfere with subsequent imaging follow up.

To address this clinical need, our R&D team, with deep expertise in the field of digestive endoscopy, has conducted continuous research and development focused on clip configuration, deployment mechanisms, and removable structures. Through multiple rounds of structural iteration, material performance validation, and clinical trials, we have strived to balance two key clinical requirements: "stable closure during the acute phase" and "safe removal after tissue healing." By overcoming the limitations of permanent-retention clips, we have successfully developed a removable Over-The-Scope Clip suitable for a wide range of clinical scenarios, achieving both acute-phase closure efficacy and favorable long-term patient outcomes.

This newly developed removable Over-The-Scope Clip is specifically designed for gastrointestinal endoscopic procedures and is indicated for closure of bleeding, perforation, and full-thickness defects in the esophagus, stomach, and colorectum. Its core innovation lies in the removable clip design, which allows physicians to safely detach and retrieve the clip during endoscopy within the optimal window of one month post-procedure, depending on the healing status of the wound. This effectively mitigates the risks of foreign-body reactions, tissue inflammation, and interference with imaging examinations associated with long-term implants。

Compared to conventional devices, this removable Over-The-Scope Clip offers multiple core features and technical advantages:

1.Removable Design for Flexible Retention or Retrieval – Meets the requirements for rigid closure and rapid hemostasis during the acute phase; allows safe removal after tissue healing, enabling fully controlled management throughout the treatment course and optimized long-term outcomes.

2. Stable Clamping with Tissue-Friendly Performance – Provides a broad grasping range and sufficient closure force to withstand gastrointestinal motility and intraluminal pressure, ensuring effective wound apposition; evenly distributed clamping force minimizes traction damage to surrounding healthy tissue.

3. High-Quality Material for Safety and Compatibility – Manufactured from superelastic nitinol with excellent biocompatibility, MRI-conditional, and non-interfering with postoperative imaging follow-up.

4. Versatile Application Across Multiple Scenarios – Compatible with all major flexible endoscopes, available in multiple sizes to accommodate various gastrointestinal lesions; minimally invasive endoscopic procedure with reduced trauma and faster recovery.

In clinical practice, this removable Over-The-Scope Clip demonstrates exceptional clinical value. Choosing a removable clip not only effectively addresses the limitations of permanent retention and insufficient closure force seen in conventional devices, but also enhances procedural success rates and long-term patient outcomes through its flexible, controlled design. Furthermore, its broad compatibility and stable performance help improve surgical efficiency and reduce complication risks, making it a cornerstone choice for elevating the standard of endoscopic care and ensuring patient safety—and an ideal minimally invasive solution for both acute and chronic gastrointestinal conditions.